Reaction monitoring

Reaction monitoring for the understanding of the process, optimization and scale-up is crucial, can save the cost, and ensure the quality of the final product.Both traditional chemical, biological production and (biological), catalytic reaction monitoring usually can provide important insights to the chemical reaction mechanism.Dynamic information can be extracted from time to process data, and is used to establish the dynamics model, the model will be used to predict conditions, implement effective process optimization and risk assessment and control.

Many technology can be used for process monitoring, including in-situ vibration spectrum method is perhaps the most popular.Using FT - IR spectrum of a major advantage is that it can be easily used in a variety of physical size, from small development reactor (< 50 cubic centimeters of container volume) to full scale production factory (> 1000 litres of container volume).In fact, the measuring instrument can be configured to operate at the scene, the measuring probe directly inserted into the reaction vessel, and through the optical fiber cable to connect to the spectrometer, this means that the cause to the operation of the process rarely interfere with (or without).In addition, the spectrum has rich details, usually can reveal information on chemical composition and physical form of high quality.

There are very few, however, only using FT - IR measurements.At least, in the process of the synthetic route of development and the subsequent transfer of other activities also provide by chromatographic analysis, the structure of the enthalpy measuring and analytical research techniques such as providing supporting data.Most of these technologies requires a calibration steps, let the output normalization, in order to provide the concentration and time data.Nuclear magnetic resonance (NMR) can play an important role in the calibration of other technologies, because it offers inherent quantitative signal based on the number of nuclear reactions, and it also is the main structure of molecular characteristics (including intermediates) analytic tool, to ensure that in the development of active pharmaceutical ingredients (APIs) usually play a powerful role.

Fourier transform infrared spectroscopy (FT - IR) and nuclear magnetic resonance (NMR) is the combination of very powerful, mechanisms of nuclear magnetic resonance (NMR) is by getting ideas to strengthen the understanding of the reaction.Online flow reaction conditions, nuclear magnetic resonance (NMR) can simulate the real realization of zero time measurement, and compared with other spectra collected at the same time.Combined with a Mid - IR, the transferring process from the lab to test or manufacturing plant, the technology improved the overall process of confidence.

Process monitoring drug made content development team to simplify the work flow, pushed new small molecules and biological drugs to reduce the time required by the market.

Brooke has a wide range of solutions and application portfolio, used to monitor the chemical and biological processes, in order to increase the reaction mechanism, the formation of free radicals, the details of the forced degradation and the understanding of the expression of cell metabolites.